Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Identifieur interne : 000601 ( Main/Exploration ); précédent : 000600; suivant : 000602Alcohol Consumption in Midlife and Cognitive Performance Assessed 13 Years Later in the SU.VI.MAX 2 Cohort
Auteurs : Emmanuelle Kesse-Guyot [France] ; Valentina A. Andreeva [France] ; Claude Jeandel [France] ; Monique Ferry [France] ; Mathilde Touvier [France] ; Serge Hercberg [France] ; Pilar Galan [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.
To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.
3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996
In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.
In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.
ClinicalTrials.gov
Url:
DOI: 10.1371/journal.pone.0052311
PubMed: 23284983
PubMed Central: 3526526
Affiliations:
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Andreeva</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Gérontologie Clinique Antonin Balmes, CHU Montpellier, Université I, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Département de Santé Publique, Hôpital Avicenne, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Santé Publique, Hôpital Avicenne, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR Inserm U557; Inra U1125; Cnam; Université Paris 13 Sorbonne Paris-Cité, CRNH Ile-de-France, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Associations between alcohol consumption and cognitive function are discordant and data focusing on midlife exposure are scarce.</p></sec><sec><title>Objective</title><p>To estimate the association between midlife alcohol consumption and cognitive performance assessed 13 y later while accounting for comorbidities and diet.</p></sec><sec><title>Methods</title><p>3,088 French middle-aged adults included in the SU.VI.MAX (1994) study with available neuropsychological evaluation 13 y later. Data on alcohol consumption were obtained from repeated 24h dietary records collected in 1994–1996<bold>.</bold> Cognitive performance was assessed in 2007–2009 via a battery of 6 neuropsychological tests. A composite score was built as the mean of the standardized individual test scores (mean = 50, SD = 10). ANCOVA were performed to estimate mean differences in cognitive performance and 95% confidence intervals (CI).</p></sec><sec><title>Results</title><p>In women, abstainers displayed lower cognitive scores than did low-to-moderate alcohol drinkers (1 to 2 drinks/day) (mean difference = −1.77; 95% CI: −3.29, −0.25). In men, heavy drinkers (>3 drinks/day) had higher cognitive scores than did low-to-moderate (1 to 3 drinks/day) (mean difference = 1.05; 95% CI: 0.10, 1.99). However, a lower composite cognitive score was detected in male drinkers consuming ≥90 g/d (≈8 drinks/d). A higher proportion of alcohol intake from beer was also associated with lower cognitive scores. These associations remained significant after adjustment for diet, comorbidities and sociodemographic factors.</p></sec><sec><title>Conclusion</title><p>In men, heavy but not extreme drinking was associated with higher global cognitive scores. Given the known harmful effects of alcohol even in low doses regarding risk of cancer, the study does not provide a basis for modifying current public health messages.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT00272428">NCT00272428</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Middleton, Le" uniqKey="Middleton L">LE Middleton</name></author><author><name sortKey="Yaffe, K" uniqKey="Yaffe K">K Yaffe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Coley, N" uniqKey="Coley N">N Coley</name></author><author><name sortKey="Andrieu, S" uniqKey="Andrieu S">S Andrieu</name></author><author><name sortKey="Gardette, V" uniqKey="Gardette V">V Gardette</name></author><author><name sortKey="Gillette Guyonnet, S" uniqKey="Gillette Guyonnet S">S 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Silbershatz</name></author><author><name sortKey="Wolf, Pa" uniqKey="Wolf P">PA Wolf</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Kesse Guyot, Emmanuelle" sort="Kesse Guyot, Emmanuelle" uniqKey="Kesse Guyot E" first="Emmanuelle" last="Kesse-Guyot">Emmanuelle Kesse-Guyot</name></region><name sortKey="Andreeva, Valentina A" sort="Andreeva, Valentina A" uniqKey="Andreeva V" first="Valentina A." last="Andreeva">Valentina A. Andreeva</name><name sortKey="Ferry, Monique" sort="Ferry, Monique" uniqKey="Ferry M" first="Monique" last="Ferry">Monique Ferry</name><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><name sortKey="Jeandel, Claude" sort="Jeandel, Claude" uniqKey="Jeandel C" first="Claude" last="Jeandel">Claude Jeandel</name><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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